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Influence of microbial environment on development of myeloid leukemia in X‐irradiated rfm mice
Author(s) -
Walburg H. E.,
Cosgrove G. E.,
Upton A. C.
Publication year - 1968
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910030118
Subject(s) - myeloid leukemia , incidence (geometry) , leukemia , bacteria , biology , myeloid , shock (circulatory) , microbiology and biotechnology , immunology , medicine , genetics , physics , optics
The incidence of radiation‐induced myeloid leukemia, to which conventionally reared RF mice are unusually susceptible, has been observed to vary among colonies of RFM mice maintained in different microbial environments. The incidence in germ‐free RFM males exposed to 300 R of X‐irradiation at 5 to 6 weeks of age was only 1%, whereas that in their conventionally reared counterparts was 13%. In similarly irradiated RFM males subjected to microbial shock by transfer from an environment containing a limited number of bacteria to a conventional microbial environment, the incidence was 20%. The results suggest that the incidence of myeloid leukemia varies inversely in relation to the bacterial “cleanliness” of the environment, possibly as a result of associated variations in granulocytopoiesis.