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The functions of membranes in neoplastic cells partially resistant to thiotepa
Author(s) -
Barton A. A.,
Barton Mary
Publication year - 1968
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910030116
Subject(s) - thiotepa , membrane , cytoplasm , cell , chemistry , matrix (chemical analysis) , cancer research , microbiology and biotechnology , biology , biochemistry , chemotherapy , genetics , chromatography , cyclophosphamide
Thiotepa causes alterations in the structure of the cytoplasmic matrix and the rapid formation of membranes. These provide the means by which the altered matrix is voided from the cell. It is suggested that this form of excretion is the method by which cells are able to resist the antineoplastic action of alkylating agents.