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Lactate dehydrogenase isoenzyme patterns in the tumour‐bearing colon
Author(s) -
Langvad E.
Publication year - 1968
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910030104
Subject(s) - isozyme , malignancy , lactate dehydrogenase , biology , pathology , enzyme , dehydrogenase , biochemistry , medicine
The lactate dehydrogenase (LDH) isoenzyme pattern of the tumour‐bearing colon has been studied in homogenates by disc‐electrophoretic separation. The preponderance of M‐LDH in malignant tissue has been confirmed. It has been shown that the isoenzyme pattern may be altered in the absence of morphological changes. Thus, the metabolic change is not specifically dependent on the existence of tumorous parenchymatous changes as currently recognized by light microscopy. It is suggested that the tumour develops within a tissue where metabolic modifications may precede the stage of morphological malignancy. It appears, therefore, that the alteration of the enzyme pattern might be symptomatic of an established, but very early, neoplastic condition, the microscopic recognition malignancy being a later development.