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The carcinogenic activities in mice of compounds related to benz[a]anthracene
Author(s) -
Boyland E.,
Sims P.
Publication year - 1967
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910020511
Subject(s) - anthracene , carcinogen , phenanthrene , chemistry , epoxide , hydrocarbon , biochemistry , organic chemistry , catalysis
The carcinogenic activities of a number of aromatic hydrocarbons have been compared with some metabolic intermediates by subcutaneous injection into C57 black mice. The monohydroxymethyl derivatives of 7,12‐dimethylbenz[a]anthracene and some related compounds were found to be active carcinogens, but were much less so than the parent hydrocarbon. Epoxides formed at the K‐region ofchrysene, benz[a]anthracene, 7‐methylbenz[a]antnracene and dibenz[a,h]anthracene produced tumours when given at highdose levels, but were not as active as the parent hydrocarbons. The epoxide derived from phenanthrene was inactive.