Premium
Comparaison des actions hépatocancérogènes de la diéthylnitrosamine et du p‐diméthylaminoazobenzène
Author(s) -
Lacassagne A.,
BuuHoï N. P.,
Giao N. B.,
Et R. Ferrando L. Hurst
Publication year - 1967
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910020504
Subject(s) - carcinogen , reserpine , chemistry , connective tissue , microbiology and biotechnology , biology , medicine , endocrinology , biochemistry , genetics
Earlier experiments carried out with the liver carcinogen p‐dimethylaminoazobenzene (DAB) have been repeated with another liver carcinogen, diethylnitrosamine (DEN). Nine different experiments were performed, using 84 male Wistar rats. The results were the reverse of those obtained with DAB. With the latter, a protein‐poor diet or a simultaneous administration of reserpine accelerates the process of cancerization, while addition to the carcinogen of certain phenolic ketones or of o,p'‐dichlorodiphenyl‐dichloroethane (o,p'‐DDD) inhibits it. With DEN, neither variations in the diet nor reserpine have any marked effect on the cancerization process, while the phenolic ketones and o,p'‐DDD accelerate it. DAB is far more toxic to the hepatocytes, whereas DEN is more toxic to the cells of the connective‐vascular system of the liver. As is the case with DAB, the carcinomas produced by DEN have their origin in biliary stem‐cells, the different histological types of the tumours merely representing varying degrees of cellular differentiation.