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The effect of isonicotinic acid hydrazide on the development of tumors
Author(s) -
Toth Bela,
Rustja Marjan
Publication year - 1967
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910020502
Subject(s) - isonicotinic acid , hydrazide , life span , inbred strain , medicine , pharmacology , endocrinology , biology , chemistry , biochemistry , organic chemistry , evolutionary biology , gene
Isonicotinic acid hydrazide (INH) was administered as a 0.1% solution in the drinking water for the life span of adult AKR inbred mice. The treatment resulted in no significant inhibitory effect on the development of malignant lymphomas which are characteristic of these animals, nor did it induce other tumors. Similar administration of INH as 0.05 and 0.15% solutions to adult randomly bred Swiss mice enhanced the formation of pulmonary adenomas, while it had no apparent inhibitory influence on the progression of other types of tumors. Single doses of 500, 400, 300, 250, 200 and 100 μg of INH were injected subcutane‐ously on the day of birth to Swiss mice, without significant tumorigenic effect. The problem of tumor induction versus inhibition is discussed.