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Erythropoietic stimulating factor (ESF) effects on induced and spontaneous murine leukemia
Author(s) -
Leaders Floyd E.,
Chapman A. L.,
Kornhaus Barbara,
Nielsen Anne H.,
Werder Alvar A.
Publication year - 1967
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910020411
Subject(s) - leukemia , endogeny , haematopoiesis , erythropoietin , incidence (geometry) , axenic , medicine , immunology , biology , endocrinology , physiology , stem cell , genetics , physics , optics , bacteria
Erythropoietin (ESF) has been found to increase the incidence of leukemia and mammary tumors in female conventional CFW w mice during a 19‐month observation period after administration of a single dose of ESF and leukemia extract. ESF alone also increased the number of leukemias in female conventional mice. These increases apparently were sex‐related. The increase in the incidence of leukemia is postulated to be through a mechanism of “activation” of endogenous virus since a similar enhancement was not recorded in ex‐axenic animals receiving similar treatment. Instead, in the ex‐axenic group ESF produced an apparent decrease in the incidence of leukemia. These observations have been related to the relative number of virus‐like particles in the tissues of the conventional and ex‐axenic CFW w mice.