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Uptake of sodium fluorene‐2‐selenonate‐ 75 Se by spleen and of sodium n‐7‐fluorenylacetamido‐2‐selenonate‐ 75 Se by tumor in mice
Author(s) -
Agrawal Krishna C.,
Ray F. E.
Publication year - 1967
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910020308
Subject(s) - spleen , fluorene , sodium , chemistry , distribution (mathematics) , tissue distribution , radiochemistry , microbiology and biotechnology , biology , medicine , organic chemistry , polymer , mathematical analysis , mathematics
Two new radioactive compounds, sodium fluorene‐2‐selenonate‐ 75 Se, (II), and sodium N‐7‐fluorenylacetamido‐2‐selenonate‐ 75 Se, (V), have been synthesized. The tissue distribution of these compounds in tumor‐bearing mice has been studied at different time intervals. The first compound localized itself in spleen, and its distribution was also studied in tumor‐free mice. This compound gave quite favorable ratios of concentration in spleen to the concentration in tissues. The use of this compound in splenic scanning is suggested. The second compound was concentrated in tumor to a greater extent than in the vital organs, from which it was eliminated later, showing the affinity of the compound for the tumor tissue.