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Immune reactivity prior to development of thymic lymphoma in C57BL mice
Author(s) -
Doell Ruth G.,
De Vaux Christiane,
Cyr St.,
Grabar Pierre
Publication year - 1967
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910020205
Subject(s) - immune system , histocompatibility , c57bl/6 , antigen , lymphoma , strain (injury) , neoplasm , spleen , immunology , biology , mouse strain , major histocompatibility complex , medicine , genetics , human leukocyte antigen , gene
The immune response of C57BL mice was tested following treatment with either irradiation or methylcholanthrene. Response to a weak histocompatibility antigen difference (male to female skin grafts) was found to be depressed after both treatments as was the response to a strong (H2) antigen difference as measured by the Simonsen graft‐versus‐host reaction. The potent immunodepressant drug 6‐mercaptopurine was found to be carcinogenic in this strain of mouse, inducing approximately 29 % thymic lymphomas when given to young mice. Females of the high spontaneous lymphoma strain AKR were found to have a markeldly decreased ability to reject male skin grafts as compared with the C57BL strain.