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A colony inhibition (CI) technique for demonstration of tumor cell destruction by lymphoid cells in vitro
Author(s) -
Hellström Ingegerd
Publication year - 1967
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910020111
Subject(s) - in vitro , isoantigens , lymphoma , immune system , antigen , biology , tumor cells , immunology , cancer research , cell , neoplasm , microbiology and biotechnology , biochemistry , genetics
A colony inhibition technique is described which was used to demonstrate that immune lymphocytes have a destructive effect on cultivated tumor target cells, if the target cells contain H‐2 isoantigens or tumor‐specific antigens foreign to the lymphocytes. Untreated allogeneic lymphocytes and lymphoma cells, added to the target cells together with phytohemagglutinin, were also effective in reducing the number of colonies formed.