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Some characteristic features of the biotransport of the cytostatic agent 1,6‐dibromo‐1,6‐dideoxy‐dulcitol
Author(s) -
Institóris László,
Piroska Horváth I.,
Pethes George
Publication year - 1967
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910020105
Subject(s) - urine , in vivo , enterohepatic circulation , chemistry , decomposition , oral administration , metabolism , pharmacology , chromatography , medicine , endocrinology , stereochemistry , biochemistry , biology , organic chemistry , microbiology and biotechnology
Abstract Aspects of the biological transport of cytostatically active 1,6‐dibromo‐1,6‐dideoxydulcitol (DBD) were studied using 82 Br‐labelled material on dogs and Yoshida tumorbearing rats. Thirty‐five per cent of the DBD dose was excreted in the urine within 12 hours. Besides unchanged DBD, metabolites containing C‐Br bonds could also be detected in the urine. In vivo, the 50% decomposition time of the C‐Br bonds in DBD is about 5 to 6 hours. One hour after administration of DBD, more than 50% of the persisting dose had entered the cells. Accumulation of the drug in the tumor tissue could not be demonstrated. A fraction of the dose enters the enterohepatic circulation.