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Absence of specific chromosome alterations in bovine lung fibroblasts exposed to rous sarcoma virus
Author(s) -
Pontén Jan,
Lithner Folke
Publication year - 1966
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910010608
Subject(s) - rous sarcoma virus , biology , virus , simian , embryo , sarcoma , virology , chromosome , in vitro , karyotype , lung , tissue culture , cell culture , pathology , genetics , medicine , gene
Bovine lung fibroblasts from individual embryos were exposed to three different strains of Rous sarcoma virus (Bryan, Engelbreth‐Holm, Schmidt‐Ruppin) in vitro . Chromosomal analysis early as well as late after infection, including cultures with advanced morphologic cell transformation, failed to disclose any aberrations exceeding the findings in control cultures grown in parallel under identical conditions. Simian virus 40, on the other hand, caused pronounced changes with widely scattered heteroploid counts and various rearrangements.