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Decreased susceptibility to the mammary tumour agent in mice with advancing age
Author(s) -
Dux Anna,
Mühlbock O.
Publication year - 1966
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910010503
Subject(s) - mammary gland , transplantation , mammary carcinoma , biology , medicine , mammary tumor , endocrinology , pathology , cancer , carcinoma , breast cancer
In mice, susceptibility to the mammary tumour agent (Bittner virus) decreases with advancing age. With the newly developed technique of transplantation of the mammary gland and of complete extirpation of all mammary glands, the role of the host and of the mammary gland with regard to the decreased susceptibility towards the mammary tumour agent was investigated. The experiments were done with female hybrids (♀ O20 × ♂ DBAf) F 1 . The susceptibility to the mammary tumour agent was determined by the percentage of mammary tumours which appeared in the transplanted glands. Comparison was made between the tumour incidence in young mammary glands transplanted into both young and old hosts and in old mammary glands transplanted into young and old hosts. Both the age of the host and the age of the mammary gland are determining factors in the development of mammary tumours. With advancing age of the host and advancing age of the mammary gland, tumour incidence in the mammary gland decreases and the induction time is longer under otherwise equal conditions.