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Rous tumors in monkeys
Author(s) -
Zilber L. A.,
Lapin B. A.,
Adgighytov F. I.,
Shevljaghyn V. Ja.,
Jakovleva L. A.
Publication year - 1966
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910010502
Subject(s) - rous sarcoma virus , macaca nemestrina , virus , biology , virology , inoculation , simian , cercopithecus aethiops , antibody , macaque , immunology , paleontology
Macaca rhesus, Macaca irus, Macaca nemestrina, Papio hamadryas and Cercopithecus aethiops monkeys are susceptible to Rous sarcoma virus (RSV) (Carr and Schmidt‐Ruppin strains). After intramuscular or subcutaneous injection of RSV‐infected chicken cell suspensions or cell‐free extracts of the chicken Rous sarcoma virus, they develop tumors at the sites of inoculation. These tumors appear after different periods of time, ranging from 15 up to 35 days after inoculation of the virus‐containing material. After an initial period of continuous growth (sometimes as long as 7 months), the tumors regress in most cases. Histologically, the tumors are polymorphous fibrosarcomas which do not produce metastases. The oncogenicity in monkeys of the Carr or Schmidt‐Ruppin strains was of no substantial difference. Only newborn or very juvenile monkeys are susceptible to Rous virus. The virus may only in some cases be isolated from the simian tumors by inoculation of tumor cell suspensions into chickens. Monkeys inoculated with Rous sarcoma virus develop virus‐neutralizing antibodies, in most cases very late.