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Studies on the aetiology of bilharzial carcinoma of the urinary bladder VI. Beta‐glucuronidases in urine
Author(s) -
AbdelTawab G. A.,
ElZoghby S. M.,
AbdelSamie Y. M.,
Zaki A.,
Saad A. A.
Publication year - 1966
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910010410
Subject(s) - urine , glucuronidase , bladder cancer , urinary system , urinary bladder , glucuronide , beta glucuronidase , enzyme , carcinoma , gastroenterology , cancer , urology , medicine , pathology , biology , biochemistry , gene expression , gene
The pH specificity of β‐glucuronidase enzymes in the urine of cancerous and noncancerous bilharzial patients was investigated. Bilharzial patients with urine pH above 6.0 and bilharzial bladder cancer patients had heterogeneous urinary β‐glucuronidase activities with distinct pH optima of 5.0 and 7.0, whereas other bilharzial patients and controls showed only the former peak. We suggest that the urinary β‐glucuronidase with a pH optimum of 7.0 is of bacterial origin. This enzyme may also influence the liberation of bladder carcinogens from their excreted glucuronide conjugates.