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Studies on allogeneic inhibition II. Inhibition of mouse tumor cell growth by In vitro contact with cells containing foreign H‐2 antigens
Author(s) -
Bergheden C.,
Hellström K. E.
Publication year - 1966
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910010407
Subject(s) - incubation , spleen , lymphoma , lymph node , in vitro , antigen , isoantigens , biology , neoplasm , cell , cancer research , pathology , immunology , microbiology and biotechnology , medicine , biochemistry
Abstract Mouse lymphoma cells were inoculated into preirradiated syngeneic hosts after incubation with lymph‐node, spleen, liver or lymphoma cells from different sources in the presence of phytohemagglutinin. Neutralization of tumor growth was detected after incubation of lymphoma target cells with added untreated or X‐irradiated normal lymphoid or liver cells or with X‐irradiated intact or ultrasonically disintegrated lymphoma cells in all cases where the added cells contained H‐2 isoantigens which were foreign to the targets.