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Comparison of nitrogen‐mustard‐sensitive and ‐resistant yoshida sarcomas
Author(s) -
Ball C. R.,
Connors T. A.,
Double J. A.,
Ujhazy V.,
Whisson M. E.
Publication year - 1966
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910010403
Subject(s) - nitrogen mustard , melphalan , nucleic acid , sarcoma , glutathione , biology , strain (injury) , chemistry , biochemistry , pathology , genetics , chemotherapy , medicine , anatomy , cyclophosphamide , enzyme
The Yoshida sarcoma and a line derived from it showing acquired resistance to alkylating agents have been compared from a number of aspects: chromosome number, growth rate, nucleic acid, protein and free thiol content. Although the degree of resistance to the alkylating agent Melphalan has been demonstrated to be at least 100 times greater than in the sensitive strain, the two tumours have been very similar in all aspects so far studied. A small, and not highly significant, increase in glutathione content of the solid resistant tumour has been the only difference so far demonstrated.