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The reaction of rabbits to rous sarcoma virus
Author(s) -
Ahlström C. G.,
Mark Joachim
Publication year - 1966
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910010108
Subject(s) - spleen , rous sarcoma virus , virus , pathology , sarcoma , biology , medicine , virology , immunology
Rous chicken sarcoma virus (strain SR) was injected intramuscularly into new‐born or young rabbits. After an interval of about 2 weeks it induced a fibromatous nodular swelling at the site of injection which always regressed spontaneously after a few weeks. Fibromatous nodules appeared in the liver and lungs after intravenous and sometimes also after intraperitoneal inoculation of the virus. Large amounts of acid mucopoly‐saccharides were found in the fibromatous lesions. In cortisone‐treated rabbits the lesions were usually larger than in untreated controls. Intravenously injected Rous virus was localized to the site of intramuscularly injected carcinogenic and non‐carcinogenic hydrocarbons, producing fibromatous nodules which, however, regressed after a few weeks. Many of the hydrocarbon‐treated rabbits showed numerous fibromatous nodules in the lungs and liver, sometimes also in the spleen and kidneys. Vessels connected to the nodules showed endovasculitis obliterans owing to an attack of the virus on the vessel wall. All attempts to transplant the rabbit tumour to new rabbits failed. Virus could be recovered from early rabbit lesions. It is assumed that the spontaneous regression of the lesions is due to antibodies against virus or against tumour‐specific antigens.