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Demonstration of a tumor‐specific antigen in spontaneously developing AKR lymphomas
Author(s) -
Wahren Britta
Publication year - 1966
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910010107
Subject(s) - antigen , cytotoxic t cell , virus , antibody , neoplasm , lymphoma , biology , virology , cancer research , immunology , pathology , medicine , in vitro , biochemistry
By using the cytotoxic technique, a tumor‐specific antigen was detected in six out of ten spontaneously developing AKR lymphomas investigated. With more sensitive methods such as induction of cytotoxic antibodies in allogeneic hosts and quantitative absorptions, a tumor antigen could be detected in all the AKR lymphomas studied. Cross‐reaction was demonstrated between the AKR tumor antigen and a tumor antigen previously reported for Gross passage A virus‐induced lymphomas. The cross‐reactivity supports the theory that Gross virus acts as one etiological agent of the AKR lymphomas.