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Granulocyte colony‐stimulating factor off‐target effect on nerve outgrowth promotes prostate cancer development
Author(s) -
Dobrenis Kostantin,
Gauthier Laurent R.,
Barroca Vilma,
Mag Claire
Publication year - 2014
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.29046
Subject(s) - prostate cancer , neurotrophic factors , cancer research , nerve growth factor , neurogenesis , metastasis , haematopoiesis , tramp , prostate , biology , progenitor cell , growth factor , granulocyte colony stimulating factor , stem cell , medicine , cancer , neuroscience , microbiology and biotechnology , receptor , chemotherapy
The hematopoietic growth factor granulocyte colony‐stimulating factor (G‐CSF) has a role in proliferation, differentiation and migration of the myeloid lineage and in mobilizing hematopoietic stem and progenitor cells into the bloodstream. However, G‐CSF has been newly characterized as a neurotrophic factor in the brain. We recently uncovered that autonomic nerve development in the tumor microenvironment participates actively in prostate tumorigenesis and metastasis. Here, we found that G‐CSF constrains cancer to grow and progress by, respectively, supporting the survival of sympathetic nerve fibers in 6‐hydroxydopamine‐sympathectomized mice and also, promoting the aberrant outgrowth of parasympathetic nerves in transgenic or xenogeneic prostate tumor models. This provides insight into how neurotrophic growth factors may control tumor neurogenesis and may lead to new antineurogenic therapies for prostate cancer.