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The role of tissue factor isoforms in cancer biology
Author(s) -
Leppert Ulrike,
Eisenreich Andreas
Publication year - 2014
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.28959
Subject(s) - gene isoform , tissue factor , biology , metastasis , angiogenesis , microbiology and biotechnology , alternative splicing , cancer cell , cancer , cancer research , genetics , gene , medicine , coagulation
Tissue Factor (TF) is an evolutionary conserved glycoprotein, which is of immense importance for a variety of biologic processes. TF is expressed in two naturally occurring protein isoforms, membrane‐bound “full‐length” (fl)TF and soluble alternatively spliced (as)TF. The TF isoform expression is differentially modulated on post‐transcriptional level via regulatory factors, such as serine/arginine‐rich (SR) proteins, SR protein kinases and micro (mi)RNAs. Both isoforms mediate a variety of physiologic‐ and pathophysiologic‐relevant functions, such as thrombogenicity, angiogenesis, cell signaling, tumor cell proliferation and metastasis. In this review, we will depict the main mechanisms regulating the TF isoform expression in cancer and under other pathophysiologic‐relevant conditions. Moreover, we will summarize and discuss the latest findings regarding the role of TF and its isoforms in cancer biology.