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Prediagnostic telomere length and risk of B‐cell lymphoma—Results from the EPIC cohort study
Author(s) -
Hosnijeh Fatemeh Saberi,
Matullo Giuseppe,
Russo Alessia,
Guarrera Simonetta,
Modica Federica,
Nieters Alexandra,
Overvad Kim,
Guldberg Per,
Tjønneland Anne,
Canzian Federico,
Boeing Heiner,
Aleksandrova Krasimira,
Trichopoulou Antonia,
Lagiou Pagona,
Trichopoulos Dimitrios,
Tagliabue Giovanna,
Tumino Rosario,
Panico Salvatore,
Palli Domenico,
Olsen Karina Standahl,
Weiderpass Elisabete,
Dorronsoro Miren,
Ardanaz Eva,
Chirlaque MariaDolores,
Sánchez MaríaJosé,
Quirós J. Ramón,
Venceslá Adoración,
Melin Beatrice,
Johansson Ann Sofie,
Nilsson Peter,
Borgquist Signe,
Peeters Petra H.,
OnlandMoret N. Charlotte,
BuenodeMesquita H. Bas,
Travis Ruth C.,
Khaw KayTee,
Wareham Nick,
Brennan Paul,
Ferrari Pietro,
Gunter Marc J.,
Vineis Paolo,
Vermeulen Roel
Publication year - 2014
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.28934
Subject(s) - quartile , lymphoma , odds ratio , medicine , follicular lymphoma , peripheral blood mononuclear cell , epidemiology , gastroenterology , oncology , pathology , biology , confidence interval , genetics , in vitro
Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B‐cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case–control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL ( i.e . the ratio of telomere repeat copy number to single gene copy number) was measured in mononuclear cell DNA of prediagnostic peripheral blood samples of 464 lymphoma cases and 464 matched controls (median time between blood collection and diagnosis, 4.6 years). Conditional logistic regression was used to analyze the association between TL and the risk of developing lymphoma and histologic subtypes. TL was significantly longer in cases compared to controls ( p = 0.01). Multivariable models showed a significantly increased risk of BCL [odds ratio (OR) = 1.66, 1.80 and 3.20 for quartiles 2–4, respectively, p ‐trend = 0.001], diffuse large B‐cell lymphoma (DLBCL) (OR = 1.20, 2.48 and 2.36 for quartiles 2–4, respectively, p ‐trend = 0.03) and follicular lymphoma (FL) (OR = 1.39, 1.90 and 2.69 for quartiles 2–4, respectively, p ‐trend = 0.02) with increasing TL. This study suggests an association between longer leucocyte TL and increased risk of BCL which was most pronounced for DLBCL and FL.