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Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: Findings from the childhood leukemia international consortium
Author(s) -
Bailey Helen D.,
Fritschi Lin,
InfanteRivard Claire,
Glass Deborah C.,
Miligi Lucia,
Dockerty John D.,
Lightfoot Tracy,
Clavel Jacqueline,
Roman Eve,
Spector Logan G.,
Kaatsch Peter,
Metayer Catherine,
Magnani Corrado,
Milne Elizabeth,
Polychronopoulou Sophia,
Simpson Jill,
Rudant Jérémie,
Sidi Vasiliki,
Rondelli Roberto,
Orsi Laurent,
Kang Alice Y.,
Petridou Eleni,
Schüz Joachim
Publication year - 2014
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.28854
Subject(s) - offspring , childhood leukemia , odds ratio , pregnancy , medicine , leukemia , confidence interval , myeloid leukemia , case control study , logistic regression , pesticide , occupational exposure , environmental health , immunology , biology , lymphoblastic leukemia , genetics , agronomy
Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have been suggested to increase risk of leukemia in the offspring. With a view to providing insight in this area we pooled individual level data from 13 case‐control studies participating in the Childhood Leukemia International Consortium (CLIC). Occupational data were harmonized to a compatible format. Pooled individual analyses were undertaken using unconditional logistic regression. Using exposure data from mothers of 8,236 cases, and 14,850 controls, and from fathers of 8,169 cases and 14,201 controls the odds ratio (OR) for maternal exposure during pregnancy and the risk of acute lymphoblastic leukemia (ALL) was 1.01 [95% confidence interval (CI) 0.78, 1.30] and for paternal exposure around conception 1.20 (95% 1.06, 1.38). For acute myeloid leukemia (AML), the OR for maternal exposure during pregnancy was 1.94 (CI 1.19, 3.18) and for paternal exposure around conception 0.91 (CI 0.66, 1.24.) based on data from 1,329 case and 12,141 control mothers, and 1,231 case and 11,383 control fathers. Our finding of a significantly increased risk of AML in the offspring with maternal exposure to pesticides during pregnancy is consistent with previous reports. We also found a slight increase in risk of ALL with paternal exposure around conception which appeared to be more evident in children diagnosed at the age of 5 years or more and those with T cell ALL which raises interesting questions on possible mechanisms.