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Six1: A critical transcription factor in tumorigenesis
Author(s) -
Wu Wangjun,
Ren Zhuqing,
Li Pinghua,
Yu Debing,
Chen Jie,
Huang Ruihua,
Liu Honglin
Publication year - 2014
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.28755
Subject(s) - homeobox , carcinogenesis , organogenesis , transcription factor , biology , function (biology) , computational biology , regulator , disease , cancer , gene , bioinformatics , genetics , medicine , pathology
In the past two decades, many studies have shown that sine oculis homeobox 1 (Six1) is a powerful regulator of organogenesis and disease, with important roles in tumorigenesis; therefore, it is important to review the biology of Six1 gene comprehensively. This review describes the function of Six1 in normal organ development, summarizes its role in several diseases, including cancer. The review will extend our understanding about the functional roles of Six1 and suggests opportunities to target Six1 for diagnostic, prognostic, and therapeutic purposes.