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The role and therapeutic implications of RING‐finger E3 ubiquitin ligases in hepatocellular carcinoma
Author(s) -
Yin Jie,
Zhu JiMin,
Shen XiZhong
Publication year - 2014
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.28717
Subject(s) - ring finger , ubiquitin , hepatocellular carcinoma , cancer research , medicine , ring (chemistry) , ubiquitin protein ligases , bioinformatics , ubiquitin ligase , biology , chemistry , genetics , organic chemistry , gene
Increasing evidence indicates that deregulation of RING‐finger ubiquitin‐protein ligases (E3s) involves in the development of hepatocellular carcinoma (HCC). These RING‐finger E3s serve as oncoproteins or tumor suppressors in HCC under specific conditions. In this review, we summarize current knowledge about abnormal RING‐finger E3s and their clinical significance in the development of HCC, and discuss parts of critical substrates for these RING‐finger E3s in detail. Furthermore, in light of success of Bortezomib in treating hematological malignancies, we describe the preclinical and clinical studies of therapeutic approaches targeting aberrant RING‐finger E3s in HCC.