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MicroRNA‐224 inhibits progression of human prostate cancer by downregulating TRIB1
Author(s) -
Lin ZhuoYuan,
Huang YaQiang,
Zhang YanQiong,
Han ZhaoDong,
He HuiChan,
Ling XiaoHui,
Fu Xin,
Dai QiShan,
Cai Chao,
Chen JiaHong,
Liang YuXiang,
Jiang FuNeng,
Zhong WeiDe,
Wang Fen,
Wu ChinLee
Publication year - 2014
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.28707
Subject(s) - downregulation and upregulation , microrna , prostate cancer , cancer research , metastasis , microarray analysis techniques , cancer , cell , microarray , medicine , biology , gene expression , gene , biochemistry , genetics
Our previous microarray data showed that microRNA‐224 (miR‐224) was downregulated in human prostate cancer (PCa) tissues compared with adjacent benign tissues. However, the underlying mechanisms by which miR‐224 is involved in PCa remain unclear. In this study, we identified TRIB1 as a target gene of miR‐224. Forced expression of miR‐224 suppressed PCa cell proliferation, invasion and migration, and promoted cell apoptosis by downregulating TRIB1. Moreover, the expression level of miR‐224 in PCa tissues was negatively correlated with that of TRIB1. miR‐224 downregulation was frequently found in PCa tissues with metastasis, higher PSA level and clinical stage, whereas TRIB1 upregulation was significantly associated with metastasis. Both miR‐224 downregulation and TRIB1 upregulation were significantly associated with poor biochemical recurrence‐free survival of patients with PCa. In conclusion, these findings reveal that the aberrant expression of miR‐224 and TRIB1 may promote PCa progression and have potentials to serve as novel biomarkers for PCa prognosis.