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Host characteristics, sun exposure, indoor tanning and risk of squamous cell carcinoma of the skin
Author(s) -
Veierød Marit B.,
Couto Elisabeth,
Lund Eiliv,
Adami HansOlov,
Weiderpass Elisabete
Publication year - 2014
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.28657
Subject(s) - medicine , relative risk , skin cancer , cohort , sunbathing , population , poisson regression , bathing , cohort study , confidence interval , incidence (geometry) , risk factor , dermatology , cancer , environmental health , pathology , physics , optics
Use of indoor tanning devices increases risk of cutaneous malignant melanoma, but the association with risk of squamous cell carcinoma (SCC) of the skin is unclear. Cohort studies of SCC risk are rare and we aimed to assess the association between SCC risk and host characteristics, sun exposure, and indoor tanning in a population‐based cohort of Norwegian and Swedish women conjunctly with SCC incidence data from national cancer registries. Host characteristics and exposure to sun and indoor tanning devices before 50‐years old were recorded by questionnaire at inclusion (30–50 years) in 1991/92. Multivariable relative risks (RRs) and 95% confidence intervals (CIs) were estimated by Poisson regression. During follow‐up of 106,548 women through December 2009, SCC was diagnosed in 141 women. Skin sensitivity to acute sun exposure was the most important pigmentation characteristic (RR = 2.73, 95% CI 1.47–5.05, for red with pain/red with pain and blisters versus brown). We found no consistent associations with sunburns and bathing vacations in the first five age decades, but a significant positive trend for bathing vacations summarized over ages 10–49 years ( P trend = 0.02). We also found significantly increased risks of SCC following indoor tanning at age 40–49 years (RR = 2.17, 95% CI 1.29–3.67, for ≥ 1 time/month versus never) and indoor tanning summarized over ages 10–49 years ( P trend = 0.001). RR for ever versus never use of indoor tanning over ages 10–49 years was 1.93 (95% CI 1.27–2.95). Propensity to burn was an important host characteristic, and bathing vacations and indoor tanning summarized over ages 10–49 years increased SCC risk.