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The network of P‐glycoprotein and microRNAs interactions
Author(s) -
LopesRodrigues Vanessa,
Seca Hugo,
Sousa Diana,
Sousa Emília,
Lima Raquel T.,
Vasconcelos M. Helena
Publication year - 2013
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.28500
Subject(s) - microvesicles , microrna , p glycoprotein , efflux , biology , multiple drug resistance , phenotype , function (biology) , drug resistance , microbiology and biotechnology , cell , cancer research , computational biology , bioinformatics , gene , genetics
Overexpression of P‐glycoprotein (P‐gp) contributes to the multidrug resistance (MDR) phenotype found in many cancer cells. P‐gp has been identified as a promising molecular target, although attempts to find successful therapies to counteract its function as a drug efflux pump have largely failed to date. Apart from its role in drug efflux, P‐gp may have other cellular functions such as being involved in apoptosis, and is found in various locations in the cell. Its expression is highly regulated, namely by microRNAs (miRNAs or miRs). In addition, P‐gp may regulate the expression of miRs in the cell. Furthermore, both P‐gp and miRs may be found in microvesicles or exosomes and may be transported to neighboring, drug‐sensitive cells. Here, we review this current issue together with recent evidence of this network of interactions between P‐gp and miRs.