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Arterial hypertension and cancer
Author(s) -
Milan Alberto,
Puglisi Elisabetta,
Ferrari Laura,
Bruno Giulia,
Losano Isabel,
Veglio Franco
Publication year - 2013
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.28334
Subject(s) - medicine , cancer , chemotherapy , blood pressure , disease , pathophysiology of hypertension , oncology , intensive care medicine , bioinformatics , biology
Arterial hypertension and cancer are two of the most important causes of mortality in the world; correlations between these two clinical entities are complex and various. Cancer therapy using old ( e.g ., mitotic spindle poisons) as well as new ( e.g ., monoclonal antibody) drugs may cause arterial hypertension through different mechanisms; sometimes the increase of blood pressure levels may be responsible for chemotherapy withdrawal. Among newer cancer therapies, drugs interacting with the VEGF (vascular endothelial growth factors) pathways are the most frequently involved in hypertension development. However, many retrospective studies have suggested a relationship between antihypertensive treatment and risk of cancer, raising vast public concern. The purposes of this brief review have then been to analyse the role of chemotherapy in the pathogenesis of hypertension, to summarize the general rules of arterial hypertension management in this field and finally to evaluate the effects of antihypertensive therapy on cancer disease.