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Nuclear factor of activated T cells—A transcription factor family as critical regulator in lung and colon cancer
Author(s) -
Daniel Carolin,
Gerlach Katharina,
Väth Martin,
Neurath Markus F.,
Weigmann Benno
Publication year - 2013
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.28329
Subject(s) - nfat , transcription factor , immune system , colorectal cancer , cancer research , biology , regulator , lung cancer , cancer , immunology , medicine , genetics , gene
Nuclear factor of activated T cells (NFAT) was first identified as a transcription factor which is activated upon T cell stimulation. Subsequent studies uncovered that a whole family of individual NFAT proteins exists with pleiotropic functions not only in immune but also in nonimmune cells. However, dysregulation of NFAT thereby favors malignant growth and cancer. Summarizing the recent advances in understanding how individual NFAT factors regulate the immune system, this review gives new insights into the critical role of NFAT in cancer development with special focus on inflammation‐associated colorectal cancer.