z-logo
Premium
Tissue metabolite profiling identifies differentiating and prognostic biomarkers for prostate carcinoma
Author(s) -
Jung Klaus,
Reszka Regina,
Kamlage Beate,
Bethan Bianca,
Stephan Carsten,
Lein Michael,
Kristiansen Glen
Publication year - 2013
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.28303
Subject(s) - metabolite , prostate cancer , prostatectomy , prostate , medicine , cancer , pathology , oncology
Metabolomic research offers a deeper insight into biochemical changes in cancer metabolism and is a promising tool for identifying novel biomarkers. We aimed to evaluate the diagnostic and prognostic potential of metabolites in prostate cancer (PCa) tissue after radical prostatectomy. In matched malignant and nonmalignant prostatectomy samples from 95 PCa patients, aminoadipic acid, cerebronic acid, gluconic acid, glycerophosphoethanolamine, 2‐hydroxybehenic acid, isopentenyl pyrophosphate, maltotriose, 7‐methylguanine and tricosanoic acid were determined within a global metabolite profiling study using gas chromatography/liquid chromatography‐mass spectrometry. The data were related to clinicopathological variables like prostate volume, tumor stage, Gleason score, preoperative prostate‐specific antigen and disease recurrence in the follow‐up. All nine metabolites showed higher concentrations in malignant than in nonmalignant samples except for gluconic acid and maltotriose, which had lower levels in tumors. Receiver ‐operating characteristics analysis demonstrated a significant discrimination for all metabolites between malignant and nonmalignant tissue with a maximal area under the curve of 0.86 for tricosanoic acid, whereas no correlation was observed between the metabolite levels and the Gleason score or tumor stage except for gluconic acid. Univariate Cox regression and Kaplan‐Meier analyses showed that levels of aminoadipic acid, gluconic acid and maltotriose were associated with the biochemical tumor recurrence (prostate‐specific antigen > 0.2 ng/mL). In multivariate Cox regression analyses, aminoadipic acid together with tumor stage and Gleason score remained in a model as independent marker for prediction of biochemical recurrence. This study proved that metabolites in PCa tissue can be used, in combination with traditional clinicopathological factors, as promising diagnostic and prognostic tools.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here