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The receptor tyrosine kinase Axl in cancer: Biological functions and therapeutic implications
Author(s) -
Paccez Juliano D.,
Vogelsang Matjaz,
Parker M. Iqbal,
Zerbini Luiz F.
Publication year - 2013
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.28246
Subject(s) - axl receptor tyrosine kinase , receptor tyrosine kinase , cancer research , gas6 , cancer , tyrosine kinase , prostate cancer , myeloid leukemia , malignancy , downregulation and upregulation , biology , medicine , receptor , jak stat signaling pathway , biochemistry , gene
The receptor tyrosine kinase Axl has been implicated in the malignancy of different types of cancer. Emerging evidence of Axl upregulation in numerous cancers, as well as reports demonstrating that its inhibition blocks tumor formation in animal models, highlight the importance of Axl as a new potential therapeutic target. Furthermore, recent data demonstrate that Axl plays a pivotal role in resistance to chemotherapeutic regimens. In this review we discuss the functions of Axl and its regulation and role in cancer development, resistance to therapy, and its importance as a potential drug target, focusing on acute myeloid leukemia, breast, prostate and non‐small cell lung cancers.