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Evaluation of risk factors for extrahepatic cholangiocarcinoma: ABO blood group, hepatitis B virus and their synergism
Author(s) -
Zhou Yu,
Zhou Quanbo,
Lin Qing,
Chen Ruiwan,
Gong Yuanfeng,
Liu Yimin,
Yu Min,
Zeng Bing,
Li Kaiwen,
Chen Rufu,
Li Zhihua
Publication year - 2013
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.28196
Subject(s) - abo blood group system , medicine , hbsag , odds ratio , hepatitis b virus , case control study , hepatitis b , gastroenterology , confounding , risk factor , confidence interval , immunology , virus
Little is known about the role of association between ABO blood group and development of extrahepatic cholangiocarcinoma (ECC) through effects on hepatitis B viral (HBV) infection. Our aim was to address this question using a matched case–control study in Southern China.We prospectively analyzed 239 ECC patients, and 478 age‐ and sex‐matched controls in Sun Yat‐sen Memorial Hospital of Sun Yat‐sen University from 1999 to 2011. Information on ABO blood group, HBV infection and other clinicopathologic factors was collected. Adjusted odds ratios (AORs) and the corresponding 95% confidence intervals (CIs) were computed from unconditional logistic regression models, adjusted for major confounding factors. The estimated AORs were as follows: A blood group, 1.784; HBsAg+/HbcAb+, 1.848 and HBsAg−/HbcAb+, 1.501. The A blood type had a significant effect on modifying the risk of ECC among subjects with HBsAg+/HbcAb+ (AOR 3.795, 95% CI 1.427–10.090). ECC patients with A blood group were more common in younger subjects, and a lower proportion of serum CA‐125 and CA19‐9 elevation in patients with blood type A was found. Our study suggests an association between A blood type, HBV infection and ECC risk, and a synergism between A blood type and HBV infection in the development of ECC.