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Long‐term regional control in the observed neck following definitive chemoradiation for node‐positive oropharyngeal squamous cell cancer
Author(s) -
Goenka Anuj,
Morris Luc G.T.,
Rao Shyam S.,
Wolden Suzanne L.,
Wong Richard J.,
Kraus Dennis H.,
Ohri Nisha,
Setton Jeremy,
Lok Benjamin H.,
Riaz Nadeem,
Mychalczak Borys R.,
Schoder Heiko,
Ganly Ian,
Shah Jatin P.,
Pfister David G.,
Zelefsky Michael J.,
Lee Nancy Y.
Publication year - 2013
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.28120
Subject(s) - medicine , chemoradiotherapy , head and neck cancer , neck dissection , stage (stratigraphy) , positron emission tomography , radiation therapy , radiology , cohort , standardized uptake value , head and neck squamous cell carcinoma , cancer , nuclear medicine , paleontology , biology
Traditionally, patients treated with chemoradiotherapy for node‐positive oropharyngeal squamous cell carcinoma (N + OPSCC) have undergone a planned neck dissection (ND) after treatment. Recently, negative post‐treatment positron‐emission tomography (PET)/computed tomography (CT) imaging has been found to have a high negative predictive value for the presence of residual disease in the neck. Here, we present the first comprehensive analysis of a large, uniform cohort of N + OPSCC patients achieving a PET/CT‐based complete response (CR) after chemoradiotherapy, and undergoing observation, rather than ND. From 2002 to 2009, 302 patients with N + OPSCC treated with 70 Gy intensity‐modulated radiation therapy and concurrent chemotherapy underwent post‐treatment clinical assessment including PET/CT. CR was defined as no evidence of disease on clinical examination and post‐treatment PET/CT. ND was reserved for patients with