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Obesity, adipokines and hepatocellular carcinoma
Author(s) -
Duan XiaoFeng,
Tang Peng,
Li Qiang,
Yu ZhenTao
Publication year - 2013
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.28105
Subject(s) - adipokine , adiponectin , resistin , hepatocellular carcinoma , medicine , leptin , cirrhosis , adipose tissue , carcinogenesis , cancer research , endocrinology , obesity , cancer , insulin resistance
Obesity is rapidly becoming pandemic and is associated with increased carcinogenesis, especially hepatocellular carcinoma (HCC). Adipose tissue is considered as an endocrine organ because of its capacity to secrete a variety of adipokines, such as leptin, adiponectin and resistin. Recently, adipokines have been demonstrated to be associated with kinds of chronic liver diseases including fibrosis, cirrhosis and carcinogenesis. Direct evidence is accumulating rapidly supporting the inhibitory and/or activating role of adipokines in the process of carcinogenesis and progression of human HCC. This review aims to provide important insight into the potential mechanisms of adipokines in the development of HCC.