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The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis
Author(s) -
Ford Caroline E.,
Qian Ma Sean Si,
Quadir Ashfaque,
Ward Robyn L.
Publication year - 2013
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.27984
Subject(s) - wnt signaling pathway , cancer research , receptor tyrosine kinase , ror1 , carcinogenesis , biology , tyrosine kinase , signal transduction , microbiology and biotechnology , receptor , cancer , genetics , platelet derived growth factor receptor , growth factor
The Wnt signaling pathway is involved in the development and progression of many human cancers, yet attempts to target the pathway therapeutically have been disappointing to date. The recent discovery that the ROR2 receptor tyrosine kinase (RTK) is a novel Wnt receptor provides the potential to target the non‐canonical Wnt pathway for cancer treatments. As a member of the RTK superfamily of surface receptors ROR2 appears to possess dual roles as a tumor suppressor or activator depending on tumor type. This review will explore the dual role of ROR2 in tumorigenesis and provide an up to date analysis of current literature in this rapidly expanding field.