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RUNX family: Regulation and diversification of roles through interacting proteins
Author(s) -
Chuang Linda Shyue Huey,
Ito Kosei,
Ito Yoshiaki
Publication year - 2012
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.27964
Subject(s) - transcription factor , biology , gene , genetics , signal transduction , microbiology and biotechnology
The Runt‐related transcription factors (RUNX) belong to an ancient family of metazoan genes involved in developmental processes. Through multiple protein‐interacting partners, RUNX proteins have been implicated in diverse signaling pathways and cellular processes. The frequent inactivation of RUNX genes in cancer indicates crucial roles for RUNX in tumor suppression. This review discusses the abilities of RUNX proteins, in particular RUNX3, to integrate oncogenic signals or environmental cues and to initiate appropriate tumor suppressive responses.