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Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations
Author(s) -
Chan Paul K.S.,
Zhang Chuqing,
Park JongSup,
SmithMcCune Karen K.,
Palefsky Joel M.,
Giovannelli Lucia,
Coutlée Francois,
Hibbitts Samantha,
Konno Ryo,
SettheethamIshida Wannapa,
Chu TangYuan,
Ferrera Annabelle,
Alejandra Picconi María,
De Marco Federico,
Woo YinLing,
Raiol Tainá,
PiñaSánchez Patricia,
Bae JeongHoon,
Wong Martin C.S.,
Chirenje Mike Z.,
Magure Tsitsi,
Moscicki AnnaBarbara,
Fiander Alison N.,
Capra Giuseppina,
Young Ki Eun,
Tan Yi,
Chen Zigui,
Burk Robert D.,
Chan Martin C.W.,
Cheung TakHong,
Pim David,
Banks Lawrence
Publication year - 2012
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.27932
Subject(s) - phylogenetic tree , biology , genetics , cervical cancer , odds ratio , sequence (biology) , cervical intraepithelial neoplasia , gene , cancer , medicine
Human papillomavirus (HPV) 58 accounts for a notable proportion of cervical cancers in East Asia and parts of Latin America, but it is uncommon elsewhere. The reason for such ethnogeographical predilection is unknown. In our study, nucleotide sequences of E6 and E7 genes of 401 HPV58 isolates collected from 15 countries/cities across four continents were examined. Phylogenetic relationship, geographical distribution and risk association of nucleotide sequence variations were analyzed. We found that the E6 genes of HPV58 variants were more conserved than E7. Thus, E6 is a more appropriate target for type‐specific detection, whereas E7 is more appropriate for strain differentiation. The frequency of sequence variation varied geographically. Africa had significantly more isolates with E6‐367A (D86E) but significantly less isolates with E6‐203G, ‐245G, ‐367C (prototype‐like) than other regions ( p ≤ 0.003). E7‐632T, ‐760A (T20I, G63S) was more frequently found in Asia, and E7‐793G (T74A) was more frequent in Africa ( p < 0.001). Variants with T20I and G63S substitutions at E7 conferred a significantly higher risk for cervical intraepithelial neoplasia grade III and invasive cervical cancer compared to other HPV58 variants (odds ratio = 4.44, p = 0.007). In conclusion, T20I and/or G63S substitution(s) at E7 of HPV58 is/are associated with a higher risk for cervical neoplasia. These substitutions are more commonly found in Asia and the Americas, which may account for the higher disease attribution of HPV58 in these areas.

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