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Non‐coding RNAs and EZH2 interactions in cancer: Long and short tales from the transcriptome
Author(s) -
Benetatos Leonidas,
Voulgaris Evangelos,
Vartholomatos George,
Hatzimichael Eleftheria
Publication year - 2012
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.27859
Subject(s) - biology , microrna , epigenetics , transcriptome , prc2 , computational biology , long non coding rna , genetics , gene , carcinogenesis , small nucleolar rna , ezh2 , polycomb group proteins , histone , genome , non coding rna , regulation of gene expression , rna , gene expression , repressor
A large amount of data indicates that non‐coding RNAs represent more than the “dark matter” of the genome. Both microRNAs and long non‐coding RNAs are involved in several fundamental biologic processes, and their deregulation may lead in oncogenesis. Interacting with the Polycomb‐repressive complex 2 subunit EZH2, they could affect the expression of protein‐coding genes and form feedback networks and autoregulatory loops. They can also form networks with upstream and downstream important factors, in which EZH2 represent the stabilizing factor of the pathway. As such non‐coding RNAs affect the epigenetic modifications leading to malignant transformation.