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Local targets for immune therapy to cancer: Tumor draining lymph nodes and tumor microenvironment
Author(s) -
Fransen Marieke F.,
Arens Ramon,
Melief Cornelis J.M.
Publication year - 2012
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.27755
Subject(s) - tumor microenvironment , lymph , immunotherapy , medicine , immune system , cancer , cancer immunotherapy , cancer therapy , tumor progression , tumor immunology , immunology , cancer research , pathology
In recent years, it has become apparent that immunoregulatory processes influence cancer development. The key players in tumor progression are mainly present in the microenvironment of the tumor and the draining lymph nodes. Interventions aimed at shifting tumor‐promoting actions toward effective tumor‐eradicating immunity are thus foremost required locally. As immune‐modulating therapy has been shown to cause many adverse side effects when administered systemically, we strongly advocate the further development of local treatment for cancer immunotherapy.