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Pre‐diagnostic alcohol consumption and breast cancer recurrence and mortality: Results from a prospective cohort with a wide range of variation in alcohol intake
Author(s) -
Holm Marianne,
Olsen Anja,
Christensen Jane,
Kroman Niels T.,
Bidstrup Pernille E.,
Johansen Christoffer,
Overvad Kim,
Tjønneland Anne
Publication year - 2012
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.27652
Subject(s) - medicine , breast cancer , prospective cohort study , cancer , cohort , cohort study , risk factor , alcohol consumption , multivariate analysis , breast disease , oncology , alcohol , biochemistry , chemistry
The association between pre‐diagnostic alcohol consumption and breast cancer recurrence and breast cancer specific mortality was investigated in 1,052 women diagnosed with early breast cancer in a prospective cohort of 29,875 women. Known clinical, lifestyle and socioeconomic risk factors were evaluated and adjusted for in multivariate analysis. We found a modest but significant association between pre‐diagnostic alcohol consumption and breast cancer recurrence with a median follow‐up of six years after date of diagnosis, both when using baseline measures of alcohol intake (HR, 1.65; 95% CI, 1.02–2.67; >2 units/day vs . ≤1 unit/day) and cumulated alcohol intake (HR, 2.02; 95% CI, 1.06–3.85; >40 drinking years vs . 0