Premium
Dietary supplement use is not associated with recurrence of colorectal adenomas: A prospective cohort study
Author(s) -
HeineBröring Renate C.,
Winkels Renate M.,
Botma Akke,
Wahab Peter J.,
Tan Adriaan C.I.T.L.,
Nagengast Fokko M.,
Witteman Ben J.M.,
Kampman Ellen
Publication year - 2012
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.27647
Subject(s) - colorectal adenoma , medicine , adenoma , prospective cohort study , hazard ratio , gastroenterology , cohort , colorectal cancer , confidence interval , cancer
Diet and lifestyle influence colorectal adenoma recurrence. The role of dietary supplement use in colorectal adenoma recurrence remains controversial. In this prospective cohort study, we examined the association between dietary supplement use, total colorectal adenoma recurrence and advanced adenoma recurrence. Colorectal adenoma cases ( n = 565) from a former case–control study, recruited between 1995 and 2002, were prospectively followed until 2008. Adenomas with a diameter of ≥1 cm and/or (tubulo)villous histology and/or with high grade dysplasia and/or ≥3 adenomas detected at the same colonic examination were considered advanced adenomas. Hazard ratios (HRs) and 95% confidence intervals (CIs) for dietary supplement users (use of any supplement during the past year) compared to nonusers and colorectal adenoma recurrence were calculated using stratified Cox proportional hazard models for counting processes and were adjusted for age, sex, educational level and number of colonoscopies during follow‐up. Robust sandwich covariance estimation was used to adjust for the within subject correlation. A number of 165 out of 565 adenoma patients had at least one colorectal adenoma recurrence during a median person‐time of 5.4 years and of these, 37 patients had at least one advanced adenoma. One‐third of the total study population ( n = 203) used a dietary supplement. Compared to no use, dietary supplement use was neither statistically significantly associated with total colorectal adenoma recurrence (HR = 1.03; 95% CI 0.79–1.34) nor with recurrent advanced adenomas (HR = 1.59; 95% CI 0.88–2.87). This prospective cohort study did not suggest an association between dietary supplement use and colorectal adenoma recurrence.