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Vitamin or mineral supplement intake and the risk of head and neck cancer: pooled analysis in the INHANCE consortium
Author(s) -
Li Qian,
Chuang ShuChun,
ElufNeto Jose,
Menezes Ana,
Matos Elena,
Koifman Sergio,
WünschFilho Victor,
Fernandez Leticia,
Daudt Alexander W.,
Curado Maria Paula,
Winn Deborah M.,
Franceschi Silvia,
Herrero Rolando,
Castellsague Xavier,
Morgenstern Hal,
Zhang ZuoFeng,
Lazarus Philip,
Muscat Joshua,
McClean Michael,
Kelsey Karl T.,
Hayes Richard B.,
Purdue Mark P.,
Schwartz Stephen M.,
Chen Chu,
Benhamou Simone,
Olshan Andrew F.,
Yu Guopei,
Schantz Stimson,
Ferro Gilles,
Brennan Paul,
Boffetta Paolo,
Hashibe Mia
Publication year - 2012
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.27405
Subject(s) - medicine , odds ratio , cancer , vitamin , cancer prevention , head and neck cancer , confidence interval , ascorbic acid , vitamin d and neurology , physiology , gastroenterology , food science , biology
Abstract To investigate the potential role of vitamin or mineral supplementation on the risk of head and neck cancer (HNC), we analyzed individual‐level pooled data from 12 case–control studies (7,002 HNC cases and 8,383 controls) participating in the International Head and Neck Cancer Epidemiology consortium. There were a total of 2,028 oral cavity cancer, 2,465 pharyngeal cancer, 874 unspecified oral/pharynx cancer, 1,329 laryngeal cancer and 306 overlapping HNC cases. Odds ratios (OR) and 95% confidence intervals (CIs) for self reported ever use of any vitamins, multivitamins, vitamin A, vitamin C, vitamin E, and calcium, beta‐carotene, iron, selenium and zinc supplements were assessed. We further examined frequency, duration and cumulative exposure of each vitamin or mineral when possible and stratified by smoking and drinking status. All ORs were adjusted for age, sex, race/ethnicity, study center, education level, pack‐years of smoking, frequency of alcohol drinking and fruit/vegetable intake. A decreased risk of HNC was observed with ever use of vitamin C (OR = 0.76, 95% CI = 0.59–0.96) and with ever use of calcium supplement (OR = 0.64, 95% CI = 0.42–0.97). The inverse association with HNC risk was also observed for 10 or more years of vitamin C use (OR = 0.72, 95% CI = 0.54–0.97) and more than 365 tablets of cumulative calcium intake (OR = 0.36, 95% CI = 0.16–0.83), but linear trends were not observed for the frequency or duration of any supplement intake. We did not observe any strong associations between vitamin or mineral supplement intake and the risk of HNC.