Premium
Human papillomavirus infection in women with and without cervical cancer in Tehran, Iran
Author(s) -
Khodakarami Nahid,
Clifford Gary M.,
Yavari Parvin,
Farzaneh Farah,
Salehpour Saghar,
Broutet Natalie,
Bathija Heli,
Heideman Daniëlle A.M.,
van Kemenade Folkert J.,
Meijer Chris J.L.M.,
Hosseini Seyed Jalil,
Franceschi Silvia
Publication year - 2011
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.26488
Subject(s) - cervical cancer , human papillomavirus , medicine , gynecology , cancer , obstetrics , virology
Abstract No data exist on the population prevalence of, or risk factors for, human papillomavirus (HPV) infection in Iran or the Middle East. Cervical specimens were obtained from 825 married women aged 18–59 years from the general population of Tehran, Iran and from 45 locally diagnosed invasive cervical cancers (ICC) according to the standardized protocol of the International Agency for Research on Cancer HPV Prevalence Surveys. HPV was detected and genotyped using a GP5+/6+ PCR‐based assay. HPV prevalence in the general population was 7.8% (95% confidence interval: 6.0–9.8) (5.1% of high‐risk types), with no significant variation by age. HPV positivity was significantly higher among divorced women, women in polygamous marriages and those reporting husband's absence from home for >7 nights/month. HPV16/18 accounted for 30 and 82.2% of HPV‐positive women in the general population and ICC, respectively. Cervical cancer prevention policies should take into account the relatively low HPV prevalence in this population.