Premium
Liver cancer and non‐Hodgkin lymphoma in hepatitis C virus‐infected patients: Results from the DANVIR cohort study
Author(s) -
Omland Lars Haukali,
Jepsen Peter,
Krarup Henrik,
Christensen Peer Brehm,
Weis Nina,
Nielsen Lars,
Obel Niels,
Sørensen Henrik Toft,
Stuver Sherri Oliver
Publication year - 2011
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.26283
Subject(s) - medicine , hepatitis c virus , hepatocellular carcinoma , population , cohort , lymphoma , hepatitis c , gastroenterology , cancer , non hodgkin's lymphoma , cohort study , immunology , virus , environmental health
Hepatitis C virus (HCV)‐infection can cause hepatocellular carcinoma (HCC) and most likely non‐Hodgkin lymphoma (NHL). No studies have compared the risk of these cancers between patients with chronic and cleared HCV‐infection. The aim of this study was to estimate the 10‐year risk of HCC and NHL in HCV‐infected patients and to compare the risk of these cancers between HCV‐infected patients and the general population in Denmark and between patients with chronic and cleared HCV‐infection. Nationwide cohorts were used: 11,975 HCV‐infected patients in the DANVIR cohort and 71,850 individuals from an age‐ and gender‐matched general population cohort. Within DANVIR, 4,158 patients with chronic HCV‐infection and 2,427 patients with cleared HCV‐infection were studied. The 10‐year risks of HCC and NHL in HCV‐infected patients were 1.0% [95% confidence interval (CI): 0.8–1.3%] and 0.1% (95% CI: 0.1–0.2%), respectively. Compared to the general population, HCV‐infected patients had a 62.91‐fold increased risk of HCC (95% CI: 28.99–136.52), a 29.97‐fold increased risk of NHL during the first year of follow‐up (95% CI: 6.08–147.84), and a 1.26‐fold increased risk of NHL after the first year (95% CI: 0.36–4.41). Chronic HCV‐infection was associated with a 4.71‐fold increased risk of HCC (95% CI: 1.67–13.32) compared to cleared HCV‐infection; 5 and 0 events of NHL occurred in patients with chronic and cleared HCV‐infection, respectively. HCC‐risk is increased substantially in HCV‐infected patients compared to the general population. Chronic as opposed to cleared HCV‐infection increases the risk of HCC and perhaps NHL.