Premium
Occupation and risk of upper aerodigestive tract cancer: The ARCAGE study
Author(s) -
Richiardi Lorenzo,
Corbin Marine,
Marron Manuela,
Ahrens Wolfgang,
Pohlabeln Hermann,
Lagiou Pagona,
Minaki Ploumitsa,
Agudo Antonio,
Castellsague Xavier,
Slamova Alena,
Schejbalova Miriam,
Kjaerheim Kristina,
Barzan Luigi,
Talamini Renato,
Macfarlane Gary J.,
Macfarlane Tatiana V.,
Canova Cristina,
Simonato Lorenzo,
Conway David I.,
McKinney Patricia A.,
Sneddon Linda,
Thomson Peter,
Znaor Ariana,
Healy Claire M.,
McCartan Bernard E.,
Benhamou Simone,
Bouchardy Christine,
Hashibe Mia,
Brennan Paul,
Merletti Franco
Publication year - 2011
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.26237
Subject(s) - medicine , odds ratio , cancer , confidence interval , relative risk , demography , surgery , sociology
We investigated the association between occupational history and upper aerodigestive tract (UADT) cancer risk in the ARCAGE European case–control study. The study included 1,851 patients with incident cancer of the oral cavity, oropharynx, hypopharynx, larynx or esophagus and 1,949 controls. We estimated odds ratios (OR) and 95% confidence intervals (CI) for ever employment in 283 occupations and 172 industries, adjusting for smoking and alcohol. Men (1,457 cases) and women (394 cases) were analyzed separately and we incorporated a semi‐Bayes adjustment approach for multiple comparisons. Among men, we found increased risks for occupational categories previously reported to be associated with at least one type of UADT cancer, including painters (OR = 1.74, 95% CI: 1.01–3.00), bricklayers (1.58, 1.05–2.37), workers employed in the erection of roofs and frames (2.62, 1.08–6.36), reinforced concreters (3.46, 1.11–10.8), dockers (2.91, 1.05–8.05) and workers employed in the construction of roads (3.03, 1.23–7.46), general construction of buildings (1.44, 1.12–1.85) and cargo handling (2.60, 1.17–5.75). With the exception of the first three categories, risks both increased when restricting to long duration of employment and remained elevated after semi‐Bayes adjustment. Increased risks were also found for loggers (3.56, 1.20–10.5) and cattle and dairy farming (3.60, 1.15–11.2). Among women, there was no clear evidence of increased risks of UADT cancer in association with occupations or industrial activities. This study provides evidence of an association between some occupational categories and UADT cancer risk among men. The most consistent findings, also supported by previous studies, were obtained for specific workers employed in the construction industry.