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Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial
Author(s) -
Bobe Gerd,
Murphy Gwen,
Albert Paul S.,
Sansbury Leah B.,
Lanza Elaine,
Schatzkin Arthur,
Cross Amanda J.
Publication year - 2011
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.26184
Subject(s) - proanthocyanidin , colorectal adenoma , lignan , medicine , odds ratio , adenoma , quartile , logistic regression , colorectal polyp , gastroenterology , confidence interval , colorectal cancer , polyphenol , colonoscopy , cancer , biology , biochemistry , botany , antioxidant
Lignans and proanthocyanidins are plant polyphenols that have shown protective properties against colorectal neoplasms in some human studies. Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to prospectively evaluate the association between lignan and proanthocyanidin intake, estimated from databases linked to a food frequency questionnaire, and adenoma recurrence in 1,859 participants of the Polyp Prevention Trial. Overall, individual or total lignans or proanthocyanidins were not associated with colorectal adenoma recurrence. However, in sex‐specific analyses, total lignan intake was positively associated with any adenoma recurrence in women (highest vs. lowest lignan intake quartile OR = 2.07, 95% CI: 1.22–3.52, p trend = 0.004) but not in men ( p interaction = 0.04). To conclude, dietary lignan and proanthocyanidin consumption were not generally related to colorectal adenoma recurrence; however, high lignan intake may increase the risk of adenoma recurrence in women.