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Leukocytes as paracrine regulators of metastasis and determinants of organ‐specific colonization
Author(s) -
Erez Neta,
Coussens Lisa M.
Publication year - 2011
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.26032
Subject(s) - effector , paracrine signalling , metastasis , biology , cancer , primary tumor , medicine , cancer research , immunology , receptor , genetics
It is now well recognized that tumor cell–host interactions regulate all aspects of cancer development. Amongst the various host response programs that facilitate primary cancer development, an emerging body of literature points to a critical role for leukocytes and their soluble mediators as regulating discrete events during primary tumor development and metastasis. This review focuses on the multiple aspects of leukocytes and their effector molecules as regulators of the metastatic process.