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Childhood hodgkin's lymphoma, non‐hodgkin's lymphoma and factors related to the immune system: The escale study (SFCE)
Author(s) -
Rudant Jérémie,
Orsi Laurent,
Monnereau Alain,
Patte Catherine,
Pacquement Hélène,
LandmanParker Judith,
Bergeron Christophe,
Robert Alain,
Michel Gérard,
Lambilliotte Anne,
Aladjidi Nathalie,
Gandemer Virginie,
Lutz Patrick,
Margueritte Geneviève,
Plantaz Dominique,
Méchinaud Françoise,
Hémon Denis,
Clavel Jacqueline
Publication year - 2011
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.25862
Subject(s) - medicine , lymphoma , breastfeeding , odds ratio , etiology , non hodgkin's lymphoma , population , pediatrics , immune system , epidemiology , attendance , confounding , immunology , environmental health , economics , economic growth
The study investigated the role of factors considered related to the early stimulation of the immune system in the aetiology of childhood lymphoma. The national registry‐based case–control study, Escale, was carried out in France over the period 2003–2004. Population controls were frequency matched with the cases on age and gender. Data were obtained from structured telephone questionnaires administered to mothers. Odds ratios (ORs) were estimated using unconditional regression models adjusted for potential confounders. Data from 128 cases of Hodgkin's lymphoma (HL) aged 5–14 years, 164 cases of non‐Hodgkin's lymphoma (NHL) aged 2–14 years and 1,312 controls were analyzed. Negative associations were observed between HL and day care attendance [OR = 0.5 (0.2–1.2)] and between HL and repeated early common infections among non‐breastfed children [OR = 0.3 (.2–0.7), p = 0.003] [OR for breastfed children: 1.0 (.5–2.1)], but not for the other factors investigated. Negative associations were observed between NHL and birth order 3 or more [OR = 0.7 (0.4–1.1)], prolonged breastfeeding [OR = 0.5 (0.3–1.0)], regular contact with farm animals [OR = 0.5 (0.3–1.0)], frequent farm visits in early life [OR = 0.6 (0.4–1.1)] and history of asthma [OR = 0.6 (0.3–1.1)]. In conclusion, the results partly support the hypothesis that an abnormal maturation of the immune system may play a role in childhood HL or NHL, and call for further investigations.