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High‐frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage
Author(s) -
Yoon Jeonghoon,
Cho Jeiwon,
Kim Namgon,
Kim DaeDuk,
Lee Eunsook,
Cheon Changyul,
Kwon Youngwoo
Publication year - 2011
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.25845
Subject(s) - microwave ablation , ablation , microwave , materials science , collateral damage , breast cancer , cancer , biomedical engineering , coaxial , medicine , telecommunications , computer science , criminology , sociology
To overcome the limits of conventional microwave ablation, a new frequency spectrum above 6 GHz has been explored for low‐power and low collateral damage ablation procedure. A planar coaxial probe‐based applicator, suitable for easy insertion into the human body, was developed for our study to cover a wideband frequency up to 30 GHz. Thermal ablations with small input power (1–3 W) at various microwave frequencies were performed on nude mice xenografted with human breast cancer. Comparative study of ablation efficiencies revealed that 18‐GHz microwave results in the largest difference in the temperature rise between cancer and normal tissues as well as the highest ablation efficiency, reaching 20 times that of 2 GHz. Thermal profile study on the composite region of cancer and fat also showed significantly reduced collateral damage using 18 GHz. Application of low‐power (1 W) 18‐GHz microwave on the nude mice xenografted with human breast cancer cells resulted in recurrence‐free treatment. The proposed microwave ablation method can be a very effective process to treat small‐sized tumor with minimized invasiveness and collateral damages.